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KMID : 0381219790110040023
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Journal of RIMSK
1979 Volume.11 No. 4 p.23 ~ p.32
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Histochemical Study on the Changes of the Number of Immunocompetent Cells on the Lesion of the Patients suffering from Stomach Cancer
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지무영/Chi, M.Y
신순현/이기환/김종숙/Shin, S.H./Lee, K.W./Kim, C.S.
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Abstract
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There are numerous evidences, suggesting immunologic roles of T-and B-cells in the´ rejections of tissue transplantion and syngeneic tumors. Some authors insisted that T-cells had great tendency to migrate to the graft rejection sites, whereas B-cells had great affinity to migrate to the metastatic sites of tumors. This combination described the migration of whole and immunoabsorbent purified splenic T-and B-cell populations from mice bearing Moloney sarcoma virus (MSV)-induced rhabdomyosarcomas. These tumors were ultimately immunologically rejected although the identity of the effector cell(s) is still a controversial issue. MSV-induced tumor regression has been correlated with the appearance of an intense mononuclear cells infiltrate whereas progressing tumors which are ultimately fatal show no such infiltration. And Elboim et al. showed that T-and B-lymphocytes from either normal or tumor-bearing mice migrate to a syngeneic tumor undergoing immunologic rejection. In contrast the migration of both T-and B-cells from tumor-bearing animals was decreased to the peripheral lymph nodes at the time of maximum tumor growth.
1. The number of infiltrated immunocompetent cells around the cancer lesions were significantly greater than that around the benign lesions of the stomach.
2. Lesser number of immunocompetent cells were found in the larger diameter(more than 4cm) malignant ulcer.
3. The number of infiltrated immunocompetent cells around the cancer lesions without metastasis were significantly greater than that around the cancer lesions with. metastasis.
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